Anti-Cancer Influence Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Breast Cancer

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Xao tam phan (Paramignya trimera (Oliv.) Guillaum) is a Vietnamese traditionally medicinal plant employed in the treating numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. This research aimed to analyze the end results of 5 various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The outcomes indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the greatest antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (apart from total flavonoids) and antioxidant capacity, in comparison with conventional and ultrasound-assisted extractions. These data reveal that the use of methanol and microwave-assisted extraction are recommended for extraction of biologically active phytochemicals from P. trimera root for application within the nutraceutical and/or pharmaceutical industries.




Drying methods, solvents and extraction methods greatly impact the phytochemical compounds and biological activity from plant materials. The aims with this study would determine the effects of various drying methods, various solvents and extraction methods around the phytochemical compounds and antioxidant capacity from Xao tam phan (Paramignya trimera) root extracted from Vietnam. The final results indicated that microwave drying was a highly effective method in removal of water regarding shortest drying time, lowest energy consumption as well as retention of phytochemical compounds and antioxidant capacity through the P. trimera root while methanol and microwave-assisted extraction were the best solvent and means for greatest extraction with the phytochemical compounds and antioxidant capacity from the P. trimera root. The findings because of this study allow retaining the very best numbers of phytochemical compounds and antioxidant capacity from the P. trimera root for potential application from the nutraceutical industry.


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