Anti-Cancer Effects Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Breast Cancer

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Xao tam phan (Paramignya trimera (Oliv.) Guillaum) is often a Vietnamese traditionally medicinal plant used in the treating numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. This study aimed to research the effects of 5 various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The results indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the maximum antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (apart from total flavonoids) and antioxidant capacity, in comparison to conventional and ultrasound-assisted extractions. These data show that the application of methanol and microwave-assisted extraction are suggested for extraction of biologically active phytochemicals from P. trimera root for application within the nutraceutical and/or pharmaceutical industries.




Drying methods, solvents and extraction methods greatly affect the phytochemical compounds and biological activity from plant materials. The aims of the study would determine the effects of various drying methods, various solvents and extraction methods on the phytochemical compounds and antioxidant capacity from Xao tam phan (Paramignya trimera) root from Vietnam. The outcomes showed that microwave drying was an efficient method in elimination of water with regards to shortest drying time, lowest energy consumption and greatest retention of phytochemical compounds and antioxidant capacity in the P. trimera root while methanol and microwave-assisted extraction were the very best solvent and way for greatest extraction of the phytochemical compounds and antioxidant capacity in the P. trimera root. The findings because of this study allow retaining the very best numbers of phytochemical compounds and antioxidant capacity from the P. trimera root for potential application within the nutraceutical industry.


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