Anti-Cancer Effect Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Cancer Of The Breast

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Xao tam phan (Paramignya trimera (Oliv.) Guillaum) can be a Vietnamese traditionally medicinal plant utilized in treating numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. These studies aimed to look into the end results of 5 various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The outcomes indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the maximum antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (except for total flavonoids) and antioxidant capacity, when compared to conventional and ultrasound-assisted extractions. These data show that the use of methanol and microwave-assisted extraction are recommended for extraction of biologically active phytochemicals from P. trimera root for application in the nutraceutical and/or pharmaceutical industries.




Drying methods, solvents and extraction methods greatly modify the phytochemical compounds and biological activity from plant materials. The aims on this study could determine the effects of drying methods, various solvents and extraction methods around the phytochemical compounds and antioxidant capacity from Xao tam phan (Paramignya trimera) root from Vietnam. The final results demonstrated that microwave drying was an efficient method in removing water when it comes to shortest drying time, lowest energy consumption as well as retention of phytochemical compounds and antioxidant capacity from the P. trimera root while methanol and microwave-assisted extraction were the best solvent and way for greatest extraction in the phytochemical compounds and antioxidant capacity in the P. trimera root. The findings from this study allow retaining the greatest numbers of phytochemical compounds and antioxidant capacity from the P. trimera root for potential application inside the nutraceutical industry.


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