The 5-Second Trick For Superantigens: Molecular Biology: Immunology, and Relevance

Endogenous SAgs [edit] Small lymphocyte stimulating (Mls) exotoxins were initially discovered in the thymic stromal cells of mice. These toxins are encoded by Droop genes that were incorporated into the mouse genome from the mouse mammary tumour infection (MMTV). The presence of these genes in the mouse genome allows the mouse to reveal the antigen in the thymus as a method of adversely choosing for lymphocytes with a variable Beta region that is susceptible to stimulation by the viral SAg.

Similar endogenous SAg-dependent choice has yet to be determined in the human genome, however endogenous Droops have been discovered and are presumed of playing an essential role in viral infection. stage 1 colon cancer treatment by the Epstein, Barr virus, for instance, is understood to trigger production of a Droop in contaminated cells, yet no gene for the contaminant has been found on the genome of the infection.

Immense Immunology Insight: How superantigens work

Similar results have been found with rabies, cytomegalovirus, and HIV. References [edit] Llewelyn M, Cohen J (March 2002). "Superantigens: microbial agents that corrupt immunity". Lancet Infect Dis. 2 (3 ): 15662. doi:10. 1016/S1473 -3099( 02 )00222-0. PMID 11944185. Li H., Llera A., Malchiodi E.L., Mariuzza R.A. The structural basis of T cell activation by superantigens.

Rev. Immunol. 1999; 17:435466. doi: 10. 1146/annurev. immunol. 17. 1.435. Sriskandan S, Faulkner L, Hopkins P (2007 ). "Streptococcus pyogenes: Insight into the function of the streptococcal superantigens". Int. J. Biochem. Cell Biol. 39 (1 ): 129. doi:10. 1016/j. biocel. 2006. 08.009. PMID 17029999. Mehindate K, Thibodeau J, Dohlsten M, Kalland T, Skaly RP, Mourad W (November 1995).

Superantigen - an overview - ScienceDirect Topics

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Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current knowledge - European Respiratory Society

doi:10. 1006/jmbi. 1997.1577. PMID 9514739. Schlievert PM (April 1982). "Enhancement of host susceptibility to deadly endotoxin shock by staphylococcal pyrogenic exotoxin type C". Contaminate. Immun. 36 (1 ): 1238. doi:10. 1128/IAI.36. 1.123-128. 1982. PMC. PMID 7042568. Alouf JE, Mller-Alouf H (February 2003). "Staphylococcal and streptococcal superantigens: molecular, biological and medical aspects".